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Sell 7-Ethyl-10-hydroxycamptothecin

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  • Company Name :Tritrust Bio-technology Co.,Ltd
  • Membership :Free member
  • Registrarion Date :2016. 04. 19
  • CountryRegion:China
  • Address:4F, Building #1, 2899 South Lianhua Road, Minhang Dist., Shanghai, China (Mainland) Shanghai Shanghai, China
  • Phone / Fax:86-021-15511609413  /  
  • Contact:Krystal   skype_chat
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Product name  7-Ethyl-10-hydroxycamptothecin
Synonyms  4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
CAS No.  86639-52-3
Molecular weight  392.4
Molecular Formula  C22H20N2O5
Melting Point  217 °C
Appearance  pale yellow to yellow crytalline powder
Assy  99.50%

SN-38 is an antineoplastic drug. It is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor) but has 1000 times more activity than irinotecan itself. In vitro cytotoxicity assays show that the potency of SN-38 relative to irinotecan varies from 2- to 2000-fold.
SN38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1.

The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolism of SN-38 predicts irinotecan toxicity, as it is then less easily excreted from the body in its SN-38 glucuronide form.

SN-38 and its glucuronide are lost into the bile and feces. It can cause the symptoms of diarrhoea and myelosuppression experienced by ~25% of the patients administered irinotecan.

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Quantity 1000kgs
Price $100
Package 25kgs/fiber drum or aluminum big
  • Related Keywords :SN-38
  • Date Posted : 2020. 06. 26

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  • Sell 7-Ethyl-10-hydroxycamptothecin

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