Name :Mango Extract Mangiferin
Source: Mango
Botanical Name :Mangifera indica
Extract part: Dried Leaf
Purity: 10%~95%
Composition: Mangiferin
Identification measure :HPLC
Appearance: Yellow Fine Powder
Source
Mangifera indica, commonly known as mango, is a species of flowering plant in the sumac and poison ivy family Anacardiaceae. It is found in the wild in Bangladesh, India and Pakistan where it is indigenous and cultivated varieties have been introduced to other warm regions of the world. It is a large fruit-tree, capable of a growing to a height and crown width of about 100 feet and trunk circumference of more than twelve feet.In this oriental system of traditional medicines, varied medicinal properties are attributed to different parts of the mango tree, both as food and medicine. It is anti-diuretic, anti-diarrheal, anti-emetic and cardiac herb.Modern research showed Mangifera indica are abundant with Mangiferin , a xanthonoid which know for its bioactivities associated with antioxidant activities.
Main Bio-active
Mangiferin is natural current amount mangoes such as Irvingia Gabonens.The molecule is a glucoside of norathyriol.Mangiferin has been traditionally used in some parts of world as anti-inflammatory, analgesic, antipyretic, antioxidant, immunomodulator, antitumor, antiviral, and anthelminthic and in obesity treatment.Laboratory study has identified a variety of potential pharmacology associated with mangiferin including antimicrobial and antioxidant activities, inhibitory effects on type II 5α-reductase in vitro,and gastroprotective and antidiabetic effects in rodents.
Functions
1. Antioxidant activity
Many researches showed Mangiferin exerts antioxidant activities via multiple mechanism.Euro J Pharmacol concluded in 2005 that in vitro antioxidant activity of mangiferin could be related to its iron-chelating properties and not merely due to the scavenging activity of free radicals.Research showed Mangiferin exerted protective effect on human umbilical vein endothelial cells against glycated proteiniron chelate induced toxicity by enhancing the level of antioxidant enzymes and reducing the amount of lipid peroxidases.Study on Agricultural and Food Chemistry conducted to investigate the antioxidant properties of alcohol solutions of mangiferin in linoleic acid/water emulsion system by the thiobarbituric acid reactive substances and by inhibiting conjugated dienes formation. Mangiferin also inhibited the hydroxyl radicals. The result of the study suggests that mangiferin can be a promising antioxidant agent.
2. Antibacterial and antifungal activities
Scientists investigated an in vitro agar diffusion technique. Mangiferin showed activity against seven bacterial species: Bacillus pumilus, Bacillus cereus, Staphylococcus aureus, Staphylococcus citreus, Escherichia coli, Salmonella agona, Klebsiella pneumoniae, one yeast, Saccharomyces cerevisiae and four fungi: Thermoascus aurantiacus, Trichoderma reesei, Aspergillus flavus and Aspergillus fumigatus.
3. Immunomodulatory effect
Mangiferin was assessed for its immunomodulatory potential by Chattopadhyay et.al who observed the suppression of the proliferative response of murine splenocytes and thymocytes with higher doses of mangiferin. Later investigation indicated that o mangiferin was effective in activating murine peritoneal macrophage .Immunostimulant promising properties was confirmed by it increase in humoral antibody (HA) titre and delayed type hypersensitivity (DTH) in mice.More researches showed potential value of Mangiferin modulating the humoral response in different immunopathological disorders ;inhibiting early and late events in T cell activation;preventing TNF-induced with IB degradation and the binding of nuclear transcription factor,NF-B to the DNA;inhibiting rat macrophage functions includingphagocytic activity and the respiratory burst.Thus, Mangiferin might be of value in treatment of diseases of immunopathological origin .
4. Antidiabetic activity
Researche confirmed significant antidiabetic activity of mangiferin
by establishing its protein tyrosine phosphatase1B (PTP1B) inhibitory activity.
They synthesized some derivatives of mangiferin and evaluated their PTP1B
inhibitory activity. PTP1B plays vital role in the potential treatment of diabetes
mellitus.
An in-vitro study was reported on Fitoterapia that Mangiferin possess α-glucosidase
inhibitory activity and suggested the potential usefulness of Mangiferin in obesity and diabetes.Mangiferin has been suggested to inhibit the glucosidase enzymes (such as sucrase, isomaltase and maltase) in rats . Mangiferin reduces blood glucose levels
by inhibiting the glucose absorption from the intestine and hence possesses both pancreatic and extrapancreatic mechanisms in its antidiabetic action. Such apparent dual actions of mangiferin enhance its efficiency. Scientists also found that Mangiferin inhibited body weight gain in experimental rats. The results of this study indicate the possible utilization of mangiferin in food products for special dietary needs like with obese people.
5. Analgesic and anti-inflammatory activity
Study showed Mangiferin exhibited a potent and dose-dependent antinociceptive effect against acetic acid test in mice. It significantly inhibited oedema formation of both carrageenan- and formalin-induced oedema in rat, guinea-pigs and mice (maximal inhibitions: 39.5, 45.0 and 48.6, respectively). The inhibitions were similar to those produced by indomethacin and sodium naproxen.
Bhatia et.al. examined the ability of mangiferin to reduce prostaglandin E(2) (PGE(2)) and 8-iso-prostaglandin F(2α) (8-iso-PGF(2α)) production by lipopolysaccharide (LPS)-activated primary rat microglia. Mangiferin potently reduced LPS-induced PGE(2) synthesis and the formation of 8-iso-PGF(2α). It also reduced LPS-induced COX-2 protein synthesis in a dose-dependent manner without modifying COX-2 transcription. It can be inferred from the study that mangiferin limits microglial activation and thus may play vital role in the mechanism of cerebral protection.
6. Antitumor and antiviral activities
Mangiferin had in vivo growth-inhibitory activity against ascitic fibrosarcoma in Swiss mice. Mangiferin was found to induce antitumor effect irrespective of the size of tumor inoculum. It was also observed to have cytotoxic effect on tumor
cells.
Mangiferin was also found to antagonize in vitro the cytopathic effect of HIV in
MT-2 cells and prevented cell death. This anti-HIV effect of mangiferin might be
associated with its effect as an interferon inducer.Research showed The cell proliferation in colonic mucosa was reduced in rats treated with mangiferin. The study supports
the potential role of mangiferin as a naturally-occurring chemopreventive agent.
It also suggests that mangiferin, a minor dietary constituent, can be used to prevent
Carcinogenesis.
Applications
Mangiferin has prominent pharmacological actions corroborated by numerous
research studies. Potential applications of Mangiferin in pharmaceutical and medical trestment ,health promote supplement for the anti-inflammatory, analgesic, antipyretic, antioxidant,immunomodulator, antitumor, antiviral, anthelmintic, antiallergic, antihistaminic,cardioprotective, anticholinergic, antiamoebic and antidiabetic effects have been found to be exerted by mangiferin .
Researches showed Irvingia Gabonens seed extract process activities in treating diabetes ,improving high cholesterol and weight loss .Such properties may be appliede in midicine ,dietary supplement ,health food , beverage, cosmetics.
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