Chromatography System

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US$ 10 ~ 1000

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Supplier Info.

Company Name Jiangsu Hanbon Science&Technology Co., LTD
Membership Free member
Registration Date2024.01.03
Country/RegionChina
CityHuaian
Contact hanbon(Mr.)

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Product Attributes

- Place of Origin China
- Supply Type OEM Service
- Condition New
- Related Keywords bioprocess chromatography

Description by Manufacturer

Hanbon advanced chromatography systems has reliable performance and flexible configuration, and can provide Bio-Lab® laboratory chromatography system, Bio-Pro® pilot&process chromatography system, etc.

ommon Principles Of Process Scale-Up: Linear Scale-Up

Linear scale-up is the most common principle used in process scale-up. By linear scale-up, we mean that we can obtain almost uniform bioprocess chromatography results from laboratory scale to pilot results or industrial production level. The core idea is to keep the column height and linear flow rate constant and only scale up the column diameter and volume flow rate. A fixed column height and linear flow rate theoretically ensures the same retention time, the number of CVs used in chromatography and the number of CVs of the eluted sample, maximizing the same purification results. Theoretically, this linear scale-up of the purification separation behavior should be very similar, thus ensuring a successful scale-up of the ion chromatography process. However, some additional factors need to be considered, including a decrease in column tube support (increased pressure drop), column efficiency/column bed instability, sample diffusion (peak spreading), and dead volume of the system and tubing.

Conversion Of Linear Flow Rates (Cm/H) To Volumetric (Ml/Min) Flow Rates

When comparing results from columns of different sizes, it is convenient to express the flow rate as a linear flow rate (cm/h). However, flow rates are often measured as volumetric flow rates (ml/min). In order to convert between linear and volumetric flow rates, one of the following equations can be used .

Linear flow rate (cm/h) to volumetric (ml/min) flow rate

Volumetric flow rate (ml/min) = linear flow rate (cm/h) / 60 x column cross-sectional area (cm2)

=Y/60×π×d2/4

Y = linear flow rate (cm/h)

d = internal diameter of the column (cm)

e.g.:

There is a glass column (inner diameter 1.6 cm), when the linear flow rate is 150 cm/h, what is the volumetric flow rate?

Y=Linear flow rate = 150cm/h

d = inner diameter of the column = 1.6 cm

Volumetric flow rate = 150 x π x 1.6 x 1.6/(60 x 4)

From volumetric flow rate (ml/min) to linear flow rate (cm/h)

Linear flow rate (cm/h) = volumetric flow rate (ml/min) x 60/column cross-sectional area (cm2)

=Z×60×4/π×d2

Z = volumetric flow rate of the column (ml/min)

d = inner diameter of the column (cm)

e.g.:

There is a glass column (inner diameter 0.5 cm), when the volumetric flow rate is 1 ml/min, what is the linear flow rate?

Z = volumetric flow rate of the column = 1 ml/min

d = inner diameter of the column = 0.5 cm

Linear flow rate = 1 x 60 x 4/(π x 0.5 x 0.5) cm/h = 305.6 cm/h

We provide chromatography step by step method , chromatography purification method , chromatography process example, anion exchange chromatography elution, equipment used for chromatography, etc. For more information, please feel free to contact us!

Price

Price US$ \ 10 ~ 1000 / Set

Product Image

Bioprocess Chromatography Related Products

Company Profile

About Jiangsu Hanbon Science&Technology Co., LTD

Membership Free member
Registration Date2024.01.03
Country/RegionChina
CityHuaian
Contact hanbon(Mr.)

Jiangsu Hanbon Science and Technology Co., Ltd, a national key high-tech enterprise focusing on the chromatography-related products, contributes to providing professional chromatographic technology products and services. Currently, the company has more than 600 employees and over 30 doctors and postgraduates. Of all the workers, more than 80% have college academic credentials or higher. A professional research and development team consisting of over 60 people are engaged in mechanical design, software design and process development. The company covers an area of 206 acres and has a construction area of 57,000 m2. It now has 2 factory areas and 1 R&D Center, and the new factory area was put into use at the end of 2018. We have the perfect quality management system, and successfully passed ISO9001 Quality System Certification, IS014001 Environmental System Certification, OHSAS18001 Occupational Health System Certification, EU CE Certification and ATEX Certification, etc.

Selling Categories

- Manufacturing & Processing Machinery >> Other Manufacturing & Processing Machinery

Keywords

biopharma purification process

Registration Date	2024/01/03(Year/Month/Date)
Buyer / Seller in EC21	Seller
Business Type	Manufacturer
Year established	1998
Employees total	101 - 500
Annual revenue	Less than USD 100,000

Contact Information Order Credit Report

Company	Jiangsu Hanbon Science&Technology Co., LTD
Address	No.1-9 jixian road, economic development zoneHuaianJiangsuChina
Phone	86 - 0517 - 83706900
Homepage	www.jshanbon.com/
Contact	hanbon

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