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Methotrexate, an organic compound with the chemical formula C20H22N8O5, is mainly used as an antifolate antitumor drug. The inhibition of dihydrofolic acid reductase hinders the synthesis of tumor cells, while suppresses the growth and propagation of tumor cells. Appearance: yellow, crystalline powder
Solubility: carbonate solution soluble in dilute alkali, acid or alkali metal, slightly soluble in dilute hydrochloric acid, almost insoluble in water, ethanol, chloroform, diethyl ether
indication
1. Systemic medication for chorionic epithelial carcinoma, malignant hydatidiform mole, all kinds of acute leukemia, breast cancer, lung cancer, head and neck cancer, digestive tract cancer, cervical cancer and malignant lymphoma, etc.
2. Arterial intubation perfusion has a good effect on head and neck cancer and liver cancer.
3. High-dose methotrexate supplemented by formyltetrahydrofolate calcium rescue (HDMTX-CFR therapy) is effective as postoperative adjuvant chemotherapy or systemic treatment for osteosarcoma, soft tissue sarcoma, malignant lymphoma, acute lymphocytic leukemia, breast cancer, ovarian cancer, and small cell lung cancer.
4, Methotrexate was started in 1988 for the treatment of rheumatoid arthritis (RA). The combination of methotrexate and biological agents such as adalimumab can more effectively relieve the disease symptoms of RA patients, slow down the progression of joint damage (X-ray display), and improve physical function. Compared with traditional drugs, biological agents such as adalimumab have strong and durable efficacy and are well tolerated.
5, can also be in ectopic pregnancy local fetal sac injection to relieve bleeding.
side effect
1. Gastrointestinal reactions mainly include stomatitis, lip ulcer, pharyngitis, nausea, vomiting, gastritis and diarrhea.
2. Bone marrow suppression is mainly manifested by the decline of white blood cells, which also has a certain impact on platelets. In severe cases, whole blood decline and skin or visceral bleeding may occur.
3, a large number of one application can cause serum alanine aminotransferase (ALT) elevation, or drug-induced hepatitis, a small amount of persistent application can cause cirrhosis.
4. Kidney damage is common in high doses, such as hematuria, proteinuria, proteinuria, oliguria, azacaemia, uremia, etc.
5, there are also alopecia, dermatitis, pigmentation and drug-induced pneumonia, etc., in the sheath or head and neck artery injection dose is too large, can appear headache, back pain, vomiting, fever and convulsions and other symptoms.
6, the use of early pregnancy can cause teratogenesis, a few patients have menstrual delay and reproductive function decline.
| Registration Date | 2023/11/30(Year/Month/Date) |
|---|---|
| Buyer / Seller in EC21 | Seller |
| Business Type | Trading Company |
| Year established | 2019 |
| Employees total | 11 - 50 |
| Annual revenue | USD 500,001 - 1,000,000 |
| Company | Hubei Micro Pharmaceutical Co.,Ltd |
|---|---|
| Address | NO.1111, YONGLI INTERNATIONAL BUILDING, HONGSHAN DISTRICT, WUHAN CITY, HUBEI PROVINCE, CHINAWuhanHubeiChina |
| Phone | 86 - 021 - 61090366 |
| Contact | billy chu |